I-Crisaborole ilungu leklasi ye-benzoxaboroles eyi-5-hydroxy-1,3-dihydro-2,1-benzoxaborole apho i-phenolicihydrogenithathelwe indawo liqela le-4-cyanophenyl.I-phosphodiesterase 4 inhibitor esetyenziselwa unyango lwe-atopic dermatitis ethambileyo ukuya kwimodareyitha ebantwaneni nakubantu abadala.Inendima njenge-phosphodiesterase IV inhibitor, iantipsoriatickunye neyeza elingeyo-steroidal elichasayo ukudumba.Yi-benzoxaborole, i-ether enevumba elimnandi kunye ne-nitrile.

I-Crisaborole yinovelioxaboroleivunywe yi-FDA nge-14 kaDisemba 2016 njenge-Eucrisa, unyango lwe-topical oluthambileyo ukuya kwi-atopic dermatitis ephakathi.Le arhente ye-non-steroidal iyasebenza ekuphuculeni ubungqongqo besifo, ukunciphisa umngcipheko wosulelo kunye nokunciphisa imiqondiso kunye neempawu kwizigulane ezineminyaka emi-2 ubudala nangaphezulu.Iyanciphisa ukuvuvukala kwendawo esikhumbeni kwaye ithintele ukugqithiswa kwesifo kunye neprofayili efanelekileyo yokhuseleko.Ulwakhiwo lwalo luqulethe aibhoroni-athomu, eyenza kube lula ukungena kwesikhumba kunye nokubopha kwiziko le-bimetal ye-phosphodiesterase 4 enzyme.Okwangoku iphantsi kophuhliso njengonyango lwangaphakathi lwe-psoriasis.

I-Crisaborole yi-Phosphodiesterase 4 Inhibitor.Indlela yokwenza i-crisaborole ifana ne-Phosphodiesterase 4 Inhibitor.