I-Relugolix isetyenziselwa ukunyanga umhlaza we-prostate emadodeni.
Amagama eBrand: Orgovyx
Udidi lweziyobisi: Antineoplastic-LHRH (GnRH) Antagonist Pituitary Suppressants
Ukufumaneka: Umyalelo ofunekayo
Ukukhulelwa: Dibana nogqirha wakho. Eli yeza linokuba yingozi kumntwana ongekazalwa.
Ukuncancisa: Dibana nogqirha phambi kokuba usebenzise

I-Relugolix ifumaneka ngomlomo, i-non-peptide gonadotropin-releasing hormone (GnRH okanye i-luteinizing hormone-releasing hormone (LHRH))) umchasi, onokusebenza kwe-antineoplastic. I-Relugolix ibophelela ngokukhuphisanayo kwaye ivalele i-receptor ye-GnRH kwi-anterior pituitary gland, ekhusela zombini i-GnRH kwi-receptor ye-GnRH kwaye inqanda ukukhutshwa kunye nokukhululwa kwehomoni ye-luteinizing (LH) kunye ne-follicle stimulating hormone (FSH). Kwamadoda, ukuvinjelwa kwe-LH secretion kuthintela ukukhululwa kwe testosterone kwiiseli zeLeydig kumastes. Ekubeni i-testosterone ifuneka ukugcina ukukhula kwe-prostate, ukunciphisa amanqanaba e-testosterone kunokuthintela ukwanda kweseli yomhlaza we-prostate oxhomekeke kwihomoni.

I-Relugolix yi-gonadotropin-releasing hormone (GnRH) i-receptor antagonist esetyenziswa kunyango lweemeko ezininzi zokuphendula i-hormone. Yavunywa okokuqala eJapan ngo-2019, phantsi kwegama le-brand Relumina, kunyango lwe-uterine fibroids, kwaye kutsha nje yi-FDA yase-United States ngo-2020, phantsi kwegama le-brand Orgovyx, kunyango lomhlaza wesibeleko. I-Relugolix iye yafundwa kwakhona kunyango lweempawu ze-endometriosis. I-Relugolix yeyokuqala (kwaye okwangoku kuphela) elawulwa ngomlomo i-GnRH receptor antagonist evunyiweyo kunyango lomhlaza wesibeleko-unyango olufanayo olufana ne [degarelix] lufuna ulawulo olungaphantsi kwesikhumba-kwaye ke lubonelela ngonyango olungelulo mthwalo kwizigulana ezinokufuna ukutyelelwa eklinikhi. kulawulo ngabasebenzi bezempilo. Ukongeza kwindlela ekulula ukuyisebenzisa ngayo, i-relugolix ibonakaliswe ukuba iphezulu ekudakaleni kwamanqanaba e testosterone xa ithelekiswa ne [leuprolide], olunye unyango lokunciphisa i-androgen olusetyenziswa kunyango lomhlaza wedlala lesinyi.

I-Relugolix yi-Gonadotropin ekhupha i-Hormone Receptor Antagonist. Indlela yokusebenza ye-relugolix ifana ne-Gonadotropin yokukhupha i-Hormone Receptor Antagonist, kunye ne-Cytochrome P450 3A Inducer, kunye ne-Cytochrome P450 2B6 Inducer, kunye ne-Breast Cancer Resistance Protein Inhibitor, kunye ne-P-Glycoprotein Inhibitor. Impembelelo ye-physiologic ye-relugolix yindlela yoNciphiso lwe-GnRH Secretion.

Ubume beMichiza