I-Relugolix isetyenziselwa ukunyanga umhlaza we-prostate emadodeni.
Amagama eBrand: Orgovyx
Udidi lweziyobisi: I-Antineoplastic-LHRH (GnRH) I-Antagonist Pituitary Suppressants
Ukufumaneka: Umyalelo ofunekayo
Ukukhulelwa: Dibana nogqirha wakho.Eli yeza linokuba yingozi kumntwana ongekazalwa.
Ukuncancisa: Dibana nogqirha phambi kokuba usebenzise

I-Relugolix ifumaneka ngomlomo, i-non-peptide gonadotropin-releasing hormone (GnRH okanye i-luteinizing hormone-releasing hormone (LHRH))) umchasi, onokusebenza kwe-antineoplastic.I-Relugolix ibophelela ngokukhuphisanayo kwaye ivalele i-receptor ye-GnRH kwi-anterior pituitary gland, ekhusela zombini i-GnRH kwi-receptor ye-GnRH kwaye inqanda ukukhutshwa kunye nokukhululwa kwehomoni ye-luteinizing (LH) kunye ne-follicle stimulating hormone (FSH).Kwamadoda, ukuvinjelwa kwe-LH secretion kuthintela ukukhululwa kwe testosterone kwiiseli zeLeydig kumastes.Ekubeni i-testosterone ifuneka ukugcina ukukhula kwe-prostate, ukunciphisa amanqanaba e-testosterone kunokuthintela ukwanda kweseli yomhlaza we-prostate exhomekeke kwihomoni.

I-Relugolix yi-gonadotropin-releasing hormone (GnRH) i-receptor antagonist esetyenziswa kunyango lweemeko ezininzi zokuphendula i-hormone.Yavunywa okokuqala eJapan ngo-2019, phantsi kwegama le-brand Relumina, kunyango lwe-uterine fibroids, kwaye kutsha nje yi-FDA yase-United States ngo-2020, phantsi kwegama le-brand Orgovyx, kunyango lomhlaza wesibeleko.I-Relugolix nayo ifundwe kunyango lwe-endometriosis.I-Relugolix yeyokuqala (kwaye ngoku kuphela) elawulwa ngomlomo i-GnRH receptor antagonist evunyiweyo kunyango lomhlaza wesibeleko-unyango olufanayo olufana ne [degarelix] lufuna ulawulo olungaphantsi kwesikhumba-kwaye ke lubonelela ngonyango olungelulo mthwalo kwizigulana ezinokufuna ukutyelelwa eklinikhi. kulawulo ngabasebenzi bezempilo.Ukongeza kwindlela ekulula ukuyisebenzisa ngayo, i-relugolix yaboniswa ukuba iphezulu ekudandathekeni kwamanqanaba e-testosterone xa ithelekiswa ne- [leuprolide], enye i-androgen yonyango esetyenziselwa ukunyanga umhlaza we-prostate.

I-Relugolix yi-Gonadotropin ekhupha i-Hormone Receptor Antagonist.Indlela yokusebenza ye-relugolix ifana ne-Gonadotropin yokukhupha i-Hormone Receptor Antagonist, kunye ne-Cytochrome P450 3A Inducer, kunye ne-Cytochrome P450 2B6 Inducer, kunye ne-Breast Cancer Resistance Protein Inhibitor, kunye ne-P-Glycoprotein Inhibitor.Impembelelo ye-physiologic ye-relugolix yindlela yoNciphiso lwe-GnRH Secretion.

Ubume beMichiza