Vericiguat yipyrazolopyridineyiyo iI-5-fluoro-1H-pyrazolo[3,4-b]pyridineapho i-amino hydrogen kwindawo yoku-1 iye yatshintshwa liqela le-2-fluorobenzyl kunyeihydrogenkwindawo ye-3 ithathelwe indawo yi-4,6-diamino-5--[(methoxycarbonyl) amino]pyrimidin-2-yl iqela.Yinto enyibilikayoiguanylatei-cyclase stimulator esetyenziselwa unyango lokungaphumeleli kwentliziyo.Inendima njengento enyibilikayoiguanylatei-cyclase activator, i-agent ye-vasodilator kunye ne-antihypertensive agent.Yiyoaminopyrimidine, apyrazolopyridine, i-carbamate ester kunye ne-organofluorine compound.

I-Vericiguat iphantsi kophando kulingo lweklinikhi i-NCT02861534 (Uphononongo lwe-Vericiguat kubathathi-nxaxheba abanokungaphumeleli kwentliziyo kunye ne-Fraction ye-Ejection eNcitshisiweyo (HFrEF) (MK-1242-001)).

IVericiguat yinto eNyibilikayoGuanylateCyclase Stimulator.Indlela yesenzo se-vericiguat ifana ne-aGuanylateCyclase Stimulator.

I-Vericiguat liyeza elisetyenziselwa ukulawula kunye nokunyanga ukungaphumeleli kwentliziyo kunye neqhekeza le-ejection elincitshisiweyo (HFrEF).Iluncedo kwisifo sentliziyo esisiba mandundu, ukusilela kwentliziyo kutsha nje.I-Vericiguat ayilwandisi ixesha lokuphila kodwa inqanda ukubuyiselwa esibhedlele.Lo msebenzi uchaza imiqondiso, indlela yokwenza, idosi, kunye nendlela yokulawula liqela le-interprofessional, iziphumo ezibi, ukuchasana, kunye nezilingo ezininzi zokuxhasa ubungqina bokuba luncedo kwechiza kwi-HFrEF.