Vericiguat yipyrazolopyridineyiyo iI-5-fluoro-1H-pyrazolo[3,4-b]pyridineapho i-amino hydrogen kwindawo yoku-1 iye yatshintshwa liqela le-2-fluorobenzyl kunyeihydrogenkwindawo ye-3 ithathelwe indawo yi-4,6-diamino-5--[(methoxycarbonyl) amino]pyrimidin-2-yl iqela. Yinto enyibilikayoiguanylatei-cyclase stimulator esetyenziselwa unyango lokungaphumeleli kwentliziyo. Inendima njengento enyibilikayoiguanylatei-cyclase activator, i-agent ye-vasodilator kunye ne-antihypertensive agent. Yiyoaminopyrimidine, apyrazolopyridine, i-carbamate ester kunye ne-organofluorine compound.

I-Vericiguat iphantsi kophando kulingo lweklinikhi i-NCT02861534 (Uphononongo lwe-Vericiguat kubathathi-nxaxheba abanokungaphumeleli kwentliziyo kunye ne-Fraction ye-Ejection eNcitshisiweyo (HFrEF) (MK-1242-001)).

I-Vericiguat yinto eNyibilikayoGuanylateCyclase Stimulator. Indlela yesenzo se-vericiguat ifana ne-aGuanylateCyclase Stimulator.

I-Vericiguat liyeza elisetyenziselwa ukulawula kunye nokunyanga ukungaphumeleli kwentliziyo kunye nokunciphisa i-ejection fraction (HFrEF). Iluncedo kwisifo sentliziyo esisiba mandundu, ukusilela kwentliziyo kutsha nje. I-Vericiguat ayandisi ixesha lokuphila kodwa inqanda ukubuyiselwa esibhedlele. Lo msebenzi uchaza imiqondiso, indlela yokusebenza, idosi, kunye nendlela yolawulo liqela leengcali, iziphumo ezibi, ukuchasana, kunye nezilingo ezininzi zokuxhasa ubungqina bokuba luncedo kwechiza kwi-HFrEF.