Imvelaphi

I-Tofacitinib citrate, eyaziwa ngokuba yi-CP-690550 citrate, i-inhibitor enamandla ye-janus kinase 3 (JAK3), i-hematopoetic cell-restricted cell-restricted tyrosine kinase ebandakanyekayo kwi-signal transduction elawula ukusinda kwe-lymphocyte, ukwanda, ukwahlula, kunye ne-apoptosis. I-inhibition yi-JAK3 ekhethekileyo kunye ne-selectivity 1000-fold more than other non-JAK family kinases. Ngaphandle kokuvimbela i-JAKS (IC50 = 1 nM), i-tofacitinib citrate iphinda ivimbele i-janus kinase 2 (JAK2) kunye ne-janus kinase 1 (JAK1) kunye ne-20- kunye ne-100-fold less in potency ngokulandelanayo. Nangona kunjalo, kuphononongo lwakutsha nje, i-affinities ebophelelayo (i-Ki) ye-tofacitinib citrate ngokubhekiselele kwi-JAK1, i-JAK2, kunye ne-JAK3 zichazwe njenge-1.6 nM, i-21.7 nM, kunye ne-6.5 nM ngokulandelanayo.

Isalathiso

ULalitha Vijayakrishnan, R. Venkataramanan kunye noPalak Gulati. Ukunyanga ukuvuvukala kunye ne-janus kinase inhibitor CP-690,550. Iimpawu kwiiSayensi zePharmacological 2011: 32 (1); 25-34

Imveliso Citation

• 1. UPanagi I, uJennings E, et al. "I-Salmonella Effector SteE Iguqula i-Mammalian Serine / i-Threonine Kinase GSK3 ibe yi-Tyrosine Kinase kwi-Direct Macrophage Polarization." I-Cell Host Microbe. 2020;27(1):41–53.e6. PMID:31862381
• 2. McInnes IB, Byers NL, et al. "Ukuthelekiswa kwe-baricitinib, i-upadacitinib, kunye ne-tofacitinib edibeneyo yokulawula umqondiso we-cytokine kwi-leukocyte subpopulations yabantu." I-Arthritis Res Ther. 2019 Agasti 2;21(1):183. PMID:31375130
• 3. ULiu S, uVerma M, nabanye. "Ukumelana ne-Steroid yohlobo lwe-2 ye-innate lymphoid cells ezivela kwizigulane ezine-asthma enzima: Indima ye-thymic stromal lymphopoietin." J Allergy Clin Immunol. 2018 Jan; 141 (1): 257-268.e6. PMID:28433687
• 4. UZheng, uLufeng, nabanye. "I-3' UTR ye-pseudogene CYP4Z2P ikhuthaza i-tumor angiogenesis kumdlavuza webele ngokusebenza njenge-ceRNA ye-CYP4Z1." Uphando lomhlaza webele kunye nonyango (2015): 1-14. PMID:25701119

Inkcazo

I-Tofacitinib citrate yi-JAK1 / 2/3 inhibitor efumaneka ngomlomo kunye ne-IC50s ye-1, i-20, kunye ne-112 nM, ngokulandelanayo. I-Tofacitinib citrate ine-antibacterial, i-antifungal kunye nemisebenzi ye-antiviral.

Ugcino

4°C, khusela ekukhanyeni

*Kwi-solvent : -80°C, iinyanga ezi-6; -20°C, inyanga eyi-1 (khusela ekukhanyeni)

Ubume beMichiza

Idatha yeBiological eNxulumeneyo

Idatha yeBiological eNxulumeneyo

Idatha yeBiological eNxulumeneyo

Idatha yeBiological eNxulumeneyo

Idatha yeBiological eNxulumeneyo