Inkcazo

I-Sugammadex sodium i-synthetic γ-cyclodextrin derivative, kwaye isebenza njenge-agent entsha yokuguqula i-neuromuscular block.

Igama leGeneric: sugammadex (soo GAM ma dex)
Igama leBrand: Bridion

I-Sugammadex iguqula imiphumo yamayeza athile anikezelwa ngexesha lotyando ukuze ukhulule imisipha yakho.

I-Sugammadex isetyenziswe ekupheleni kokuhlinzwa, ukunceda ukubuyisela umsebenzi we-muscle oye wavinjelwa ngexesha lotyando ngamanye amayeza.

I-Sugammadex ingasetyenziselwa iinjongo ezingadweliswanga kwesi sikhokelo samayeza.

Isetyenziselwa ukubuyisela umva iziphumo zamanye amachiza.

KwiVivo

I-injection ye-sugammadex ayinayo imiphumo ebalulekileyo kuxinzelelo lwegazi okanye izinga lentliziyo. Emva kwe-injection ye-dose ephezulu ye-rocuronium, i-90% yokubuyisela umlinganiselo we-train-of-four ithatha i-28 min (SD 7 min) emva kwe-saline, i-26 min (SD 9.5 min) emva kwe-1 mg / kg sugammadex, kunye ne-8 min (SD) I-3.6 min) emva kwe-2.5 mg / kg sugammadex [1]. I-Sugammadex ibangela ukuguqulwa ngokukhawuleza kunye nokupheleleyo kwe-rocuronium-induced neuromuscular block. Ixesha lokubuyisela ukuqeqeshwa kwe-4 ratio = 0.9 emva kokubuyisela ngokuzenzekelayo yi-14.4 min (SD = 3.4 min; n = 14). Oku kuncitshiswe kakhulu kwi-3.7 min (SD = 3.3 min; n = 4) kunye ne-sugammadex 0.5 mg / kg kunye ne-1.9 min (SD = 1.0 min; n = 4) kunye ne-sugammadex 1.0 mg / kg [2]. Uqikelelo lwesiqingatha sobomi be-sugammadex kwi-Rhesus monkey yi-30 (SEM = 4.9) min[3].

Ugcino

Ubume beMichiza