Inkcazo

I-Rosuvastatin Calcium (i-BANM, JAN, USAN) yaziwa ngokuba yiRosuvastatin e-US.kunye ne-HMG-CoA reductase inhibitor ekhuphisanayo ene-IC50 ye-11 nM[1].I-Rosuvastatin Calcium ivimbela ngokunamandla i-ether-a-go-go yejini enxulumene ne-ether-go-go (i-hERG) yangoku kunye ne-IC50 ye-195 nM, ukulibaziseka kwe-cardiac repolarization, kwaye ngaloo ndlela ithatha ixesha elide elinokubakho (APDs) kunye nokulungiswa kwexesha le-QT (QTc) [2].I-Rosuvastatin Calcium inciphisa ukubonakaliswa kwe-hERG evuthiweyo kunye nokusebenzisana kweprotheyini yokutshatyalaliswa kokushisa kwe-70 (Hsp70) kunye neprotheni ye-hERG.I-Rosuvastatin Calcium isebenza kakhulu ekunciphiseni i-low-density lipoprotein (LDL) i-cholesterol, i-triglycerides, kunye ne-C-reactive protein level [3].

Ulwazi oluthe vetshe malunga nezivumelwano zokuthiywa kweziyobisi: Amagama angengowobunikazi bamazwe ngamazwe.

Isaziso esiBalulekileyo: I-database ye-Drugs.com yamazwe ngamazwe ikukukhululwa kwe-BETA.Oku kuthetha ukuba isephantsi kophuhliso kwaye inokuqulatha izinto ezingachanekanga.Ayenzelwanga endaweni yobuchule kunye nesigwebo sikagqirha wakho, usokhemesti okanye omnye umsebenzi wezempilo.Akufanele kuthatyathwe ukubonisa ukuba ukusetyenziswa kwawo nawaphi na amayeza nakweliphi na ilizwe kukhuselekile, kufanelekile okanye kuyasebenza kuwe.Dibana nengcali yezempilo phambi kokuba uthathe nawaphi na amayeza.

E-US, i-Rosuvastatin (i-rosuvastatin systemic) lilungu le-statins yeklasi yeziyobisi kwaye isetyenziselwa ukunyanga i-Atherosclerosis, i-Cholesterol ephezulu, i-Cholesterol ephezulu - i-Heterozygous ye-Family, i-Cholesterol ephezulu - i-Homozygous ye-Family, i-Hyperlipoproteinemia, i-Hyperlipoproteinemia Uhlobo lwe-IIa - i-LDL ephezulu, i-Hyperlipopro I-IIb - i-LDL ephakanyisiweyo ye-VLDL, i-Hyperlipoproteinemia Uhlobo lwe-III - I-beta-VLDL IDL ephakamileyo, i-Hyperlipoproteinemia Uhlobo lwe-IV - i-VLDL ephakamileyo, i-Hypertriglyceridemia kunye noThintelo lwe-Cardiovascular Disease.

Imvelaphi

I-inhibitor ekhethiweyo, ekhuphisanayo ye-HMG-CoA reductase, ekwayi-antilipemic.

Ugcino

Ubume beMichiza