Inkcazo

I-Pitavastatin Calcium (NK-104 hemicalcium) inamandla e-hydroxymethylglutaryl-CoA (HMG-CoA) i-reductase inhibitor.I-Pitavastatin Calcium (NK-104 hemicalcium) inqanda i-cholesterol synthesis kwi-acetic acid kunye ne-IC50 ye-5.8 nM kwiiseli ze-HepG2.I-Pitavastatin Calcium yi-hepatocyte esebenzayo i-low-density lipoprotein-cholesterol (LDL-C) inducer ye-receptor.Umsebenzi wokulwa nomhlaza.

Imvelaphi

I-Pitavastatin Calcium yi-inhibitor ekhuphisanayo ye-enzyme ye-HMGCR (i-HMG-CoA reductase) iphumela ekunciphiseni i-LDL ye-cholesterol synthesis.Olunye uphando lubonisa ukuba i-pitavastatin inokucinezela ukuveliswa kwe-oksijini kwiiseli ze-endothelial ngokuvimbela i-NADPH oxidase.Ukongeza, i-pitavastatin inciphisa intetho ye-eNOS mRNA ngelixa inyusa i-NO impendulo exhomekeke kuyo ekhuthazwa yi-acetylcholine kunye ne-calcium ionophore, i-A23187.Ngaphezu koko, i-pitavastatin inqanda ukulawulwa kwe-calcium-activated potassium channels ngokunciphisa amanqanaba e-cholesterol kwiiseli.

Ugcino

4°C, ukukhusela ekukhanyeni

*kwi-solvent : -80°C, iinyanga ezi-6;-20°C, inyanga e-1 (khusela ekukhanyeni)

Ubume beMichiza

Idatha yeBiological eNxulumeneyo