Inkcazo

I-Pitavastatin Calcium (NK-104 hemicalcium) inamandla e-hydroxymethylglutaryl-CoA (HMG-CoA) i-reductase inhibitor. I-Pitavastatin Calcium (NK-104 hemicalcium) inqanda i-cholesterol synthesis kwi-acetic acid kunye ne-IC50 ye-5.8 nM kwiiseli ze-HepG2. I-Pitavastatin Calcium yi-hepatocyte ephantsi-density lipoprotein-cholesterol (LDL-C) receptor inducer. Umsebenzi wokulwa nomhlaza.

Imvelaphi

I-Pitavastatin Calcium yi-inhibitor ekhuphisanayo ye-enzyme ye-HMGCR (i-HMG-CoA reductase) iphumela ekunciphiseni i-LDL ye-cholesterol synthesis. Olunye uphando lubonisa ukuba i-pitavastatin inokucinezela ukuveliswa kwe-oksijini kwiiseli ze-endothelial ngokuvimbela i-NADPH oxidase. Ukongeza, i-pitavastatin inciphisa intetho ye-eNOS mRNA ngelixa inyusa i-NO impendulo exhomekeke kuyo ekhuthazwa yi-acetylcholine kunye ne-calcium ionophore, i-A23187. Ngaphezu koko, i-pitavastatin inqanda ukulawulwa kwe-calcium-activated potassium channels ngokunciphisa amanqanaba e-cholesterol kwiiseli.

Ugcino

4°C, ukukhusela ekukhanyeni

*kwi-solvent : -80°C, iinyanga ezi-6; -20°C, inyanga enye (khusela ekukhanyeni)

Ubume beMichiza

Idatha yeBiological eNxulumeneyo