Ruxolitinibluhlobo lwechiza lomhlaza ekujoliswe kulo.Isetyenziselwa ikakhulu ukuthintela ukusebenza kwendlela yokubonisa i-JAK-STAT kunye nokunciphisa umqondiso ocinezela ukuphuculwa okungaqhelekanga, ngaloo ndlela ukuphumeza umphumo wonyango.Isebenza ngokuthintela umzimba wakho ekuveliseni izinto ezibizwa ngokuba yimiba yokukhula.Ayinakunyanga kuphela isifo esisodwa kwindawo ye-hematology yonyango, kodwa iphinde iphathe i-classical myeloproliferative neoplasms (ebizwa ngokuba yi-BCR-ABL1-negative MPNs), i-JAK exon 12 utshintsho, i-CALR, kunye ne-APL, njl.
Leliphi ithamo lokuqala elicetyiswayo?
Inokubangela iziphumo ebezingalindelekanga ezibandakanya i-myelosuppression ngokunjalo, ekhokelela ekubonakaliseni okunqabileyo, kodwa okunokuba yingozi eklinikhi enjenge-neutropenia, i-thrombocytopenia, i-leukemia kunye ne-anemia.Ngoko ke kufuneka kuthathelwe ingqalelo ekhethekileyo ekumiseleni iidosi zokuqalisa xa kumiselwa izigulane.Idosi yokuqala ecetyiswayo ye-Ruxolitinib ikakhulu ixhomekeke kwisibalo se-PLT yesigulana.Kwizigulane ezine-platelet count engaphezu kwama-200, umthamo wokuqala ngu-20 mg kabini yonke imihla;Kulabo abane-platelet count kuluhlu lwe-100 ukuya kwi-200, umthamo wokuqala ngu-15 mg kabini imihla ngemihla;Kwizigulane ezine-platelet count phakathi kwe-50 kunye ne-100, umthamo wokuqala wokuqala ngu-5 mg kabini yonke imihla.
Izilumkiso ngaphambi kokuthathaRuxolitinib
Okokuqala, khetha ugqirha onamava atyebileyo kunyango ngeRuxolitinib.Xelela ugqirha wakho ukuba awuhambisani nayo, okanye ukuba unayo nayiphi na enye i-allergies.Isenokuba nezithako ezingasebenziyo, ezinokubangela ukuguquguquka okanye ezinye iingxaki.
Okwesibini, vavanya rhoqo amanani akho ePLT.Ubalo lwegazi olupheleleyo kunye nenani leplatelet kufuneka lirekhodwe rhoqo kwiiveki ezi-2-4 ukususela ekuthatheni i-Ruxolitinib de iidosi zizinzile, kwaye emva koko zivavanywe ukuba izikhombisi zeklinikhi zifuna njalo.
Okwesithathu, lungisa iidosi ngokufanelekileyo.Idosi yokuqala ayifane ihlengahlengiswe ukuba uthatha i-Ruxolitinib kodwa ube nenani eliphantsi leplatelet ekuqaleni.Xa isibalo sakho se-PLT sinyuka njengoko unyango olujoliswe kuyo luqhubeka, ungayandisa idosi yakho ngokuthe ngcembe ngokulandela imiyalelo kagqirha wakho ngononophelo.
Okokugqibela, xelela ugqirha wakho ngembali yakho yezonyango, ngakumbi iingxaki ze-myeloproliferative ezifana nesifo sezintso, isifo sesibindi, kunye nomhlaza wolusu.Amanye amayeza okanye unyango kufuneka endaweni ye-Ruxolitinib ukuba awufanelekanga.
Ixesha lokuposa: Apr-25-2022