Inkcazo

IHydrochlorothiazide (HCTZ), ichiza lomchamo elisebenzayo ngomlomo leklasi yethiazide, inqanda ukuguqula iTGF-β/Indlela yokubonisa iSmad.IHydrochlorothiazide ineziphumo ezithe ngqo zemithambo-luvo ngokuvula umjelo we-calcium-activated potassium (KCA).IHydrochlorothiazide iphucula ukusebenza kwentliziyo, inciphisa i-fibrosis kwaye inomphumela we-antihypertensive.

Imvelaphi

IHydrochlorothiazide lichiza le-diuretic lodidi lwe-thiazide.

I-In vitro

IHydrochlorothiazide yeyodidi lwe-thiazide ye-diuretics.Inciphisa umthamo wegazi ngokusebenza kwizintso ukunciphisa i-sodium (Na) i-reabsorption kwi-distal convoluted tubule.Indawo enkulu yesenzo kwi-nephron ibonakala kwi-electroneutral ye-Na + -Cl co-transporter ngokukhuphisana nesiza se-chloride kwi-transporter.Ngokuphazamisa i-Na transport kwi-distal convoluted tubule, i-hydrochlorothiazide ibangela i-natriuresis kunye nokulahlekelwa kwamanzi okuhambelanayo.I-Thiazides yandisa ukubuyiswa kwakhona kwe-calcium kweli candelo ngendlela engahambelani nokuthuthwa kwe-sodium.Ukongeza, ngezinye iindlela, iHydrochlorothiazide ikholelwa ukuba ithoba ukuchasana kwemithambo yegazi.

I-Hydrochlorothiazide (i-HCTZ; i-oral bygavage; i-12.5 mg / kg / d; iiveki ze-8) iphucule umsebenzi wenhliziyo, yanciphisa i-cardiac interstitial fibrosis kunye ne-collagen volume fraction, ukunciphisa ukubonakaliswa kwe-AT1, TGF-β kunye ne-Smad2 kwiithishu zentliziyo kwindoda endala ye-Sprague Dawley rats.Ukongeza, i-hydrochlorothiazide inciphisa i-plasma angiotensin II kunye namanqanaba e-aldosterone.Ngapha koko, i-hydrochlorothiazide inqanda i-angiotensin II-induced TGF-βI-1 kunye ne-Smad2 inkcazo yeprotheni kwi-neonatal rat ventricular fibroblasts.

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