Inkcazo

IHydrochlorothiazide (HCTZ), ichiza lomchamo elisebenzayo ngomlomo leklasi yethiazide, inqanda ukuguqula iTGF-β/Indlela yomqondiso weSmad. IHydrochlorothiazide ineziphumo ezithe ngqo zokuphumza imithambo ngokuvula umjelo we-calcium-activated potassium (KCA). IHydrochlorothiazide iphucula ukusebenza kwentliziyo, inciphisa i-fibrosis kwaye inefuthe le-antihypertensive.

Imvelaphi

IHydrochlorothiazide lichiza le-diuretic lodidi lwe-thiazide.

I-In vitro

IHydrochlorothiazide yeyodidi lwe-thiazide ye-diuretics. Inciphisa umthamo wegazi ngokusebenza kwizintso ukunciphisa i-sodium (Na) i-reabsorption kwi-distal convoluted tubule. Indawo enkulu yesenzo kwi-nephron ibonakala kwi-electroneutral ye-Na + -Cl co-transporter ngokukhuphisana nesiza se-chloride kwi-transporter. Ngokuphazamisa ukuhamba kwe-Na kwi-tubule e-distal convoluted, i-hydrochlorothiazide ibangela i-natriuresis kunye nokulahlekelwa kwamanzi okuhambelanayo. I-Thiazides yandisa ukubuyiswa kwakhona kwe-calcium kweli candelo ngendlela engahambelani nokuthuthwa kwe-sodium. Ukongezelela, ngezinye iindlela, i-Hydrochlorothiazide ikholelwa ukuba iyancipha ukuxhathisa kwe-vascular peripheral.

I-Hydrochlorothiazide (i-HCTZ; i-oral bygavage; i-12.5 mg / kg / d; iiveki ze-8) iphucule umsebenzi wenhliziyo, yanciphisa i-cardiac interstitial fibrosis kunye neqhekeza levolumu ye-collagen, ukunciphisa ukubonakaliswa kwe-AT1, TGF-β kunye ne-Smad2 kwiithishu zentliziyo kumadoda amadala e-Sprague Dawley rats. Ukongeza, i-hydrochlorothiazide inciphisa i-plasma angiotensin II kunye namanqanaba e-aldosterone. Ngapha koko, i-hydrochlorothiazide inqanda i-angiotensin II-induced TGF-βI-1 kunye ne-Smad2 inkcazo yeprotheni kwi-neonatal rat ventricular fibroblasts.

Ubume beMichiza