China Bictegravir 1611493-60-7 abavelisi kunye nabanikezeli |CPF

I-Bictegravir 1611493-60-7

Inkcazelo emfutshane:

Igama le-API	Isalathiso	Umqalisi	Umhla wokuphelelwa kwePatent(e-US)
I-Bictegravir 1611493-60-7	Usulelo lwe-HIV-1	Inzululwazi yaseGiliyadi	Ngomhla we-19 kuDisemba 2033

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

IINKCUKACHA ZEMVELISO

Inkcazo

I-Bictegravir yinoveli, inhibitor enamandla ye-HIV-1 integrase ene-IC50 ye-7.5 nM.

I-In vitro

I-Bictegravir (BIC) inqanda umsebenzi wogqithiselo lwe-strand nge-IC50 ye-7.5± 0.3 nM.Ngokubhekiselele ekuthinteleni kwayo umsebenzi wokudluliselwa kwe-strand, i-Bictegravir sisithinteli esibuthathaka kakhulu se-3."-ukwenziwa komsebenzi we-HIV-1 IN, kunye ne-IC50 ye-241±51 nM.I-Bictegravir yongeza uqokelelo lwezangqa ze-2-LTR ~ 5-fold-fold xa kuthelekiswa nolawulo oluqhutyiweyo kwaye inciphisa ubungakanani beemveliso ezibunyani zokudibanisa kwiiseli ezosulelekileyo ngokuphindwe kayi-100.I-Bictegravir inqanda uphindaphindo lwe-HIV-1 kuzo zombini iiseli ze-MT-2 kunye ne-MT-4 ezine-EC50s ze-1.5 kunye ne-2.4 nM, ngokulandelelanayo.I-Bictegravir ibonisa iziphumo ezinamandla ze-antiviral kuzo zombini ii-lymphocytes ze-CD4+ T eziphambili kunye ne-monocyte-derived macrophages, kunye ne-EC50s ye-1.5±0.3 nM kunye 6.6±4.1 nM, ngokulandelanayo, ezithelekiseka kumaxabiso afunyenwe kwimigca ye-T-cell[1].

I-MCE ayizange iqinisekise ngokuzimeleyo ukuchaneka kwezi ndlela.Zenzelwe ireferensi kuphela.

Inombolo ye-NCT	Umxhasi	Imeko	Umhla wokuqala	Isigaba
NCT03998176	IYunivesithi yaseNebraska \| iSayensi yaseGiliyadi	HIV-1-usulelo	Nge-9 ka-Okthobha 2019	Inqanaba lesi-4
NCT03789968	IYunivesithi yaseThomas Jefferson \| IYunivesithi yaseMaryland, iPaki yeKholeji \| Impilo yeDyunivesithi yaseIndiana \| Iziko lesibhedlele saseBrooklyn \| IYunivesithi yaseIllinois eChicago \| IYunivesithi yaseNova kuMazantsi mpuma \| IYunivesithi yaseCalifornia, eSan Francisco	HIV+AIDS	NgoSeptemba 1, 2019
NCT04249037	IYunivesithi yaseColorado, eDenver \| iSayensi yaseGiliyadi	HIV+AIDS	Ngomhla woku-1 kuMatshi, ngo-2020	Ayingeni
NCT04132674	Vancouver Izifo ezosulelayo Centre	Usulelo lwe-Human Immunodeficiency virus I\|Ukusetyenziswa kweziyobisi	NgoNovemba 26, 2018	Inqanaba lesi-4
NCT04054089	Cristina Mussini\|Dyunivesithi yaseModena kunye neReggio Emilia	Usulelo lwe-HIV	NgoSeptemba 2019	Inqanaba lesi-4
NCT04155554	Azienda Ospedaliera Universitaria Senese\|Catholic University of Sacred Heart\|Ospedale Policlinico San Martino\|Azienda Ospedaliera San Paolo\|Ospedale Amedeo di Savoia	HIV-1-usulelo	NgoJanuwari 29, 2020	Inqanaba lesi-3
NCT02275065	Inzululwazi yaseGiliyadi	HIV-1 Usulelo	Okthobha 2014	Inqanaba loku-1
NCT03711253	IYunivesithi yaseSouthern California	Ukosulelwa yi-HIV eAcute	ngo-Okthobha 14, 2019	Inqanaba lesi-4
NCT02400307	Inzululwazi yaseGiliyadi	HIV	NgoAprili 17, 2015	Inqanaba loku-1
NCT03499483	Fenway Community Health	UThintelo lwe-HIV	NgoJanuwari 24, 2019	Inqanaba lesi-4
NCT03502005	IQela loPhando laseMidland, Inc.\|Nzululwazi yaseGiliyadi	Intsholongwane kaGawulayo yoMntu	NgoMatshi 1, 2018	Inqanaba lesi-4