Rimegepant
I-Rimegepant yi-molecule encinci inhibitor yeicalcitonini-peptide ehlobene ne-gene (CGRP) i-receptor evimba isenzo se-CGRP, i-vasodilator enamandla ekholelwa ukuba idlala indima kwintloko ye-migraine. I-Rimegepant ivunyiwe kunyango lokuhlaselwa kwe-acute migraine. Kulingo lweklinikhi, i-rimegepant yayinyamezeleke ngokubanzi kunye neemeko ezinqabileyo kuphela zokunyuka kwe-serum aminotransferase okwethutyana ngexesha lonyango kwaye akukho ziganeko zichaziweyo zokwenzakala kwesibindi okubonakalayo.
I-Rimegepant ngumchasi womlomo we-CGRP receptor eyenziwe yi-Biohaven Pharmaceuticals. Ifumene imvume ye-FDA nge-27 kaFebruwari 2020 yonyango oluqatha lwentloko yentloko. Ngelixa abachasi abaninzi be-CGRP kunye ne-receptor yayo baye bavunywa kunyango lwe-migraine (umz. [erenumab], [fremanezumab], [galcanezumab]), i-rimegepant kunye [ubrogepant] ngamalungu kuphela osapho lwe "gepants" lwamayeza aseleyo kuphuhliso, kwaye kuphela ngabachasi beCGRP abanobukhona be-oral bioavailability. Umgangatho wangoku wonyango lwe-migraine ubandakanya unyango lokukhupha isisu kunye ne "triptans", ezifana [sumatriptan], kodwa la mayeza anqatshelwe kwizigulane ezine-cerebrovascular and cardiovascular disease esele zikhona ngenxa yeempawu zabo ze-vasoconstrictive. I-Antagonism ye-CGRP yendlela iye yaba yinto ekujoliswe kuyo ekhangayo yonyango lwe-migraine njengoko, ngokungafaniyo ne-triptans, abachasayo be-CGRP yomlomo ababoni iimpawu ze-vasoconstrictive kwaye ngoko ke zikhuselekile ukusetyenziswa kwizigulane ezine-contraindications kunyango oluqhelekileyo.
IRimegepant yiCalcitoninI-Gene-related Receptor Antagonist. Indlela yokwenza i-rimegepant ifana ne-aCalcitoninI-Gene-related Receptor Antagonist.





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Inkqubo yolawulo lomgangatho wehlabathi ephucukileyo ibeke isiseko esiluqilima sokuthengisa.

Ukongamela umgangatho kuqhuba umjikelo wobomi bemveliso ukuqinisekisa umgangatho kunye nesiphumo sonyango.

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Korea Countec Bottled Packaging Line


Taiwan CVC Bottled UkuPakisha Line


Italy CAM Board Packaging Line

Umatshini wokuQinisa iFette waseJamani

Japan Viswill Tablet Detector

I-DCS Control Room

