2. I-Thalidomide kwi-tumor cachexia
I-Oncologic cachexia, i-syndrome ephambili yomhlaza ebonakaliswe yi-anorexia, ukuncipha kwezicubu kunye nokuncipha kobunzima, ngumceli mngeni omkhulu kukhathalelo lwe-palliative yomhlaza ophezulu.
Ngenxa yokusinda okufutshane kunye nomgangatho ombi wobomi bezigulana ezinomhlaza ophezulu, inani lezifundo kwizifundo zeklinikhi lincinci, kwaye uninzi lwezifundo ziye zavavanya kuphela ukusebenza kwexesha elikufutshane kunye neziphumo ezibi zexesha elisondeleyo zethalidomide, ngoko ke ixesha elide- ukusebenza kwexesha elide kunye neziphumo ezibi zexesha elide ze-thalidomide kunyango lwe-oncologic cachexia zisafuna ukuphononongwa kwizilingo zeklinikhi ezinobungakanani beesampulu ezinkulu.
3. Iziphumo ezibi ezinxulumene nonyango lwe-thalidomide
Ukuphendula okungalunganga okufana ne-chemotherapy-related nausea kunye nokuhlanza kunokuchaphazela ukusebenza kwe-chemotherapy kunye nokunciphisa umgangatho wobomi bezigulana. Nangona i-neurokinin i-1 ye-receptor antagonists inokuphucula kakhulu ukusabela okungalunganga okufana ne-nausea kunye nokuhlanza, isicelo sabo seklinikhi kunye nokukhuthazwa kunzima ngenxa yobume bezoqoqosho bezigulane kunye nezinye izizathu. Ke ngoko, ukukhangela iyeza elikhuselekileyo, elisebenzayo nelingabizi kakhulu lokuthintela kunye nokunyanga isicaphucaphu kunye nokuhlanza okunxulumene nechemotherapy kube yingxaki engxamisekileyo yeklinikhi.
4. Isiphelo
Ngophuhliso oluqhubekayo lwesiseko kunye nophando lweklinikhi, ukusetyenziswa kwethalidomidekunyango lwamathumba aqinileyo axhaphakileyo iye yanda, kwaye ukusebenza kwayo kwezonyango kunye nokhuseleko kuye kwaqatshelwa kwaye kwabonelelwa ngezicwangciso ezintsha zonyango kwizigulana. I-Thalidomide ikwaluncedo kunyango lwe-tumor cachexia kunye ne-chemotherapy-eyanyaniswa nesicaphucaphu kunye nokuhlanza. Ngexesha lamayeza onyango oluchanekileyo, kubalulekile ukujonga abantu abaninzi kunye ne-tumor subtypes ezisebenzayothalidomideunyango kunye nokufumana i-biomarkers eqikelela ukusebenza kwayo kunye nemiphumo emibi.