I-Ruxolitinib luhlobo lonyango olujoliswe ngomlomo olubizwa ngokuba yi-kinase inhibitor kwaye isetyenziselwa ukuphatha izifo ezifana ne-graft-versus-host disease, i-erythroblastosis, kunye ne-medium-and high-risk myelofibrosis, ngelixa i-Ruxolitinib cream i-agent ye-dermatological agent esetyenziswayo. ngqo eluswini ukunyanga eczema, vitiligo, atopic dermatitis, kunye nempandla. Nangona i-Ruxolitinib kunye ne-Ruxolitinib cream zahluke kakhulu enye kwenye, zibhideka ngokulula kuba zinegama elifanayo. I-Changzhou Pharmaceutical Factory (CPF), ehamba phambiliUmthengisi weRuxolitinibe China, apha uhlalutya umahluko phakathi kwabo ngokwemiqathango imiba emithathu enkulu ukukunceda wazi ngakumbi ngazo.
1. Isalathiso
I-Ruxolitinibyamkelwa yi-FDA ngoNovemba ka-2011 kunye neKhomishini yaseYurophu ngo-Agasti 2012 kwaye luhlobo lwechiza ekujoliswe kulo elinezalathisi ezicacileyo. Isetyenziselwa ukunyanga izigulane ezithwaxwa zizifo ezithathu, kubandakanywa i-steroid-refractory acute graft-versus-host disease, i-erythroblastosis, kunye ne-moderate-to-high risk myelofibrosis (MF). Kodwa i-cream ye-Ruxolitinib ikwinqanaba lophuhliso kwaye iyasilela ukuya kwimarike, ngoko iyiyeza eliqhelekileyo lokunyanga isifo se-shin kunye nempandla kwaye akukho zibonakaliso ezivunyiweyo okwangoku. Nangona kunjalo, uphando lubonise ukugqwesa kwekliniki ye-Ruxolitinib cream kunyango lwe-vitiligo, i-atopic dermatitis kunye nenkqayi enzima.
2. Indlela yokufaka isicelo
I-Ruxolitinib i-oral kinase inhibitor esebenza njenge-molecule encinci inhibitor ye-protein kinases JAK1 kunye ne-JAK2, kwaye iyona mayeza okuqala avunywe yi-FDA ukuphatha i-myelofibrosis. Kodwa i-Ruxolitinib cream yikhrimu yesicelo se-topical eyahluke kakhulu kwi-Ruxolitinib ngendlela esetyenziswa ngayo.
3. Impembelelo yecala
I-Ruxolitinib ineempembelelo ezicacileyo. Iziphumo ezixhaphakileyo ze-hematologic ezihambelana nokusetyenziswa kwayo ziyancipha ukubala kweplatelet kunye ne-anemia, kwaye iziphumo eziqhelekileyo ze-non-hematologic zi-petechiae, isiyezi kunye nentloko. Nangona kunjalo, i-Ruxolitinib cream isekulingo lwezonyango, ngoko ke iziphumo zayo ebezingalindelekanga azimiselwanga.
Qhagamshelana ne-CPF ukuze ufumane i-Ruxolitinib ngexabiso elifikelelekayo, kwaye uye kwiphulo lolingo lwezonyango lokufumana i-Ruxolitinib cream simahla.
Ixesha lokuposa: May-12-2022