Iipilisi ze-Atorvastatin calcium kunye neepilisi ze-rosuvastatin calcium zombini ziziyobisi ze-statin lipid-ukwehlisa, kwaye zombini zingamachiza e-statin anamandla. Iiyantlukwano ezithile zezi zilandelayo:

1. Ngokombono we-pharmacodynamics, ukuba idosi iyafana, i-lipid-ukwehla umphumo we-rosuvastatin unamandla kune-atorvastatin, kodwa kwi-dose eqhelekileyo ekhuthazwa yiklinikhi, umphumo wokunciphisa i-lipid wamachiza amabini ngokusisiseko uyafana. ;

2. Ngokubhekiselele kwiyeza elisekelwe kubungqina, ekubeni i-atorvastatin ikhoyo kwimarike ngaphambili, kukho ubungqina obuninzi be-atorvastatin kwi-cardiovascular and cerebrovascular disease kune-rosuvastatin; 3. Ngokubhekiselele kwimetabolism yeziyobisi, kukho umahluko othile phakathi kwezi zimbini. I-Atorvastatin ikakhulu i-metabolized sisibindi, ngelixa kuphela inxalenye encinci ye-rosuvastatin i-metabolized sisibindi. Ngoko ke, i-atorvastatin ithandwa kakhulu kwintsebenziswano yeziyobisi ebangelwa yi-enzyme yeziyobisi zesibindi;

4. I-Atorvastatin inokuba nemiphumo emibi yesibindi kune-rosuvastatin. Xa kuthelekiswa ne-atorvastatin, iziphumo ebezingalindelekanga ze-rosuvastatin zinokuthi zenzeke kwizintso. Ngamafutshane, i-atorvastatin kunye ne-rosuvastatin zombini iziyobisi ezinamandla ze-statin lipid-ukwehlisa, kwaye kunokubakho ukungafani kwi-metabolism yeziyobisi, ukusebenzisana kweziyobisi, kunye nokuphendula okubi.