Kwiminyaka yakutshanje, ukuthengiswa kweapixabanzikhule ngokukhawuleza, kwaye imarike yehlabathi sele igqithilei-rivaroxaban.Ngenxa yokuba uEliquis (apixaban) inenzuzo ngaphezu kwewarfarin ekuthinteleni i-stroke kunye nokopha, kunye neXarelto (Rivaroxaban) ibonise kuphela ukungabi phantsi.Ukwengeza,Apixabanayifuni luhlengahlengiso oluntsonkothileyo lwedosi, kwaye iyeza lilungele ngakumbi.Olu luhlu lokungalungi lubangelei-rivaroxabanukuphulukana nomhlaba kwimarike yaseMelika.

Nangona kunjalo, kwilizwe laseTshayina,i-rivaroxabaninezibonakaliso ezininzi kwihlabathi nakwilizwe laseTshayina.Ixesha lokuphela kwepatent yei-rivaroxabanisondele, kwaye ukufumaneka kwechiza kuya kubangela abantu abaninzii-rivaroxabanamayeza enziwe afana nalawo enziwe afana nalawo enziwe ngabenzi ukuba ngaphaya ngokubonakalayoApixaban.

Ngokutsho kwedatha ye-Xianda, intengiso yemarike yasekhaya ye-rivaroxaban ngo-2018 yayiyi-2.8 yebhiliyoni ye-yuan.Ngokwesaziso seHuahai Pharmaceutical, intengiso yentengiso yesibhedlele sasekhaya yei-rivaroxabanngo-2018 ibiyi-1.527 yeebhiliyoni zeeyuan.

Kakade ke, ukudweliswa kwamachiza enziwe afana nalawo aveliswe ngabenzi kuyakukhokelela ekwehleni kakhulu kwexabiso losuku olunye lwei-rivaroxaban.Uthathela ingqalelo ukuba kuzo zonke ii-NOAC, amalungelo awodwa omenzi wechizai-rivaroxabaniikhompawundi ziphelelwa ngo-2020 kwangoko (amalungelo awodwa omenzi wechizaapixabankunye ne-dabigatran etexilate zinde Ixesha elide), ngokungathandabuzekiyo kuya kuba luncedo ekukhuthazeni ngokupheleleyoi-rivaroxabanamayeza enziwe afana nalawo enziwe afana nalawo aveliswe ngumenzi ukuze athathe indawo yewarfarin.Ukuba ixabiso lemihla ngemihlai-rivaroxabanamayeza enziwe afana nalawo enziwe afana nalawo aveliswe ngumenzi aqaliswa ukusuka kwi-yuan eyi-27.6 ukuya kwi-yuan eyi-2.76, lo mkhwa nawo uya kuqiniswa.

Inani lezicelo eziqwalasela kuphela izigulane ezine-fibrillation ye-atrial (AF) nayo iyamangalisa.Inani lezigulane ezine-fibrillation ye-atrial e-China malunga ne-10 yezigidi, malunga nezigidi ezi-2 ze-fibrillation ye-valvular atrial kunye ne-7 yezigidi ze-non-valvular atrial fibrillation.Uvavanyo ngo-2016 Kufunyaniswe ukuba izinga lokwazisa nge-fibrillation ye-atrial kwi-Mainland yase-China yi-40%, kunye ne-anticoagulation rate yi-30%.I-Rivaroxaban ilungele ukusetyenziswa, ayifuni ukujongwa ngokuqhelekileyo kwezikhombisi ze-coagulation, kwaye izinga le-anticoagulation liya kuphuculwa kakhulu.Kuqikelelwa ukuba iyeza elenziwe lafana nelo lomenzi wei-rivaroxabaniya kuba seMainland China.Ubungakanani beemarike ezisetyenziswa kwizigulane ezine-non-valvular fibrillation ye-atrial kunye ne-fibrillation ye-atrial: izigulane ezizigidi ezisi-7 * i-30% ye-anticoagulation rate * i-50% yezinga lokungena * 2.76 yuan / ngosuku * 365 iintsuku = 157 yezigidi zeeyuan.

Ukongeza, amathuba entengiso othintelo kunye nonyango lwezigulane ze-VTE ajongelwa phantsi.Ngokwezibalo ze-VTE Prevention and Treatment Centre e-United States, inani lezigulane ze-VTE e-United States liphezulu njenge-900,000 ngonyaka, kwaye inani labantu abafa nge-VTE lifikelela kwi-60,000 ukuya kwi-100,000, kwaye kukho iingxaki zexesha elide (ezifana ne-DVT) izigulane zibalelwa kwi-50%, kwaye inani lokuphinda libuyele kwiminyaka eyi-10 libalelwa kwi-33%.

Ngenxa yokuguga kwabantu baseTshayina, kwaye isiseko sabemi singaphezulu kwe-4 amaxesha ase-United States (abantu abayi-1.395 billion).Kunokuqikelelwa ukuba kukho i-3.6 yezigidi zezigulane ze-VTE e-China ngonyaka.Kucingelwa ukuba izinga lonyango lweenyanga ezi-3 zei-rivaroxabanyi-80%, ubukhulu bemarike bu: 3.6 yezigidi zezigulane * 80% izinga lonyango * 2.76 yuan / ngosuku * iintsuku ezingama-92 = 731 yezigidi zeeyuan.

Ke ngoko, ekubaleni kuphela imiqondiso emibini ye-AF kunye ne-VTE, ubungakanani bemarike yasekhaya yamachiza enziwe afana nalawo enziwe yi-rivaroxaban busondele kwi-2 yeebhiliyoni zeeyuan.Kwanele ukwenza ukuba iinkampani zasekhaya zonyango zikhawuleze ukufaka isicelo soluhlu.

Thina,Changzhou Pharmaceutical Factory, kananjalo velisaapxiabankwayerivaroxban, kwaye bobabini bane-DMF.Rivaroxabaniphantsi kwenkqubo yokusetyenziswa kwe-CEP kunye neWC.