Dabigatran Etexilate Mesylate
Inkcazo
I-Dabigatran etexilate mesylate (BIBR 1048MS) yimveliso yomlomo esebenzayo yeDabigatran. I-Dabigatran etexilate mesylate ineempembelelo ze-anticoagulant kwaye isetyenziselwa i-prophylaxis ye-venousthromboembolism kunye ne-stroke ngenxa ye-fibrillation ye-atrial.
Imvelaphi
Inkcazo: Ixabiso le-IC50: 4.5nM (Ki); I-10nM(i-Thrombin-induced platelet aggregation) [1] I-Dabigatran ibuyiselwa umva kwaye ikhetha, i-thrombin inhibitor ethe ngqo (i-DTI) iphantsi kophuhliso oluphezulu lwekliniki njengeprodrug esebenzayo ngomlomo, i-dabigatran etexilate. kwi-vitro: I-Dabigatran ikhetha kwaye ibuyele umva i-thrombin yomntu (Ki: 4.5 nM) kunye ne-thrombin-induced platelet aggregation (IC (50): 10 nM), ngelixa ingabonakali impembelelo yokuthintela kwezinye ii-agent ezivuselela i-platelet. -i-plasma embi (PPP), ilinganiswa njenge-thrombin engapheliyo (ETP) yayinqandekile i-concentration-dependently (IC (50): 0.56 microM). I-Dabigatran ibonise iziphumo ze-anticoagulant ezixhomekeke kugxininiso kwiintlobo ezahlukeneyo ze-vitro, ngokuphindwe kabini ixesha elisebenzayo le-thromboplastin (aPTT), ixesha le-prothrombin (PT) kunye nexesha le-ecarin lokuvala (ECT) kwi-PPP yabantu kwi-concentrations ye-0.23, 0.83 kunye ne-0.18 microM, ngokulandelanayo [ 1]. kwi-vivo: I-Dabigatran yandisa ixesha le-APTT-ngokuxhomekeka emva kokulawulwa kwe-intravenous kwiigundane (0.3, 1 kunye ne-3 mg / kg) kunye ne-rhesus monkeys (0.15, 0.3 kunye ne-0.6 mg / kg). I-dose- kunye nexesha elixhomekeke kwimiphumo ye-anticoagulant yabonwa kunye ne-dabigatran etexilate elawulwa ngomlomo kwiigundane eziqaphelayo (i-10, i-20 kunye ne-50 mg / kg) okanye i-rhesus monkeys (1, 2.5 okanye i-5 mg / kg), kunye nemiphumo ephezulu ebonwa phakathi kwe-30 kunye ne-120 imizuzu emva kolawulo, ngokulandelelana [1]. Izigulane eziphathwe nge-dabigatran etexilate zifumana i-ischemic strokes embalwa (i-3.74 dabigatran etexilate vs 3.97 warfarin) kunye ne-haemorrhages embalwa edibeneyo ye-intracranial kunye ne-haemorrhagic strokes (0.43 dabigatran etexilate vs 0.99 warfarin] ngonyaka we-10) ngonyaka we-10. Ulingo lwezonyango: Uvavanyo lwe-Pharmacokinetics kunye ne-Pharmacodynamics ye-Oral Dabigatran Etexilate kwi-Hemodialysis izigulane. Isigaba1
Ugcino
| Umgubo | -20°C | Iminyaka emi-3 |
| 4°C | iminyaka eyi-2 | |
| Kwi-solvent | -80°C | Iinyanga ezi-6 |
| -20°C | Inyanga eyi-1 |
Ulingo lwezonyango
| Inombolo ye-NCT | Umxhasi | Imeko | Umhla wokuqala | Isigaba |
| NCT02170792 | Boehringer Ingelheim | Usempilweni | NgoFebruwari 2001 | Inqanaba loku-1 |
| NCT02170974 | Boehringer Ingelheim | Usempilweni | Julayi 2004 | Inqanaba loku-1 |
| NCT02170831 | Boehringer Ingelheim | Usempilweni | Meyi 1999 | Inqanaba loku-1 |
| NCT02170805 | Boehringer Ingelheim | Usempilweni | Epreli 2001 | Inqanaba loku-1 |
| NCT02170610 | Boehringer Ingelheim | Usempilweni | Matshi 2002 | Inqanaba loku-1 |
| NCT02170909 | Boehringer Ingelheim | Usempilweni | Disemba 2004 | Inqanaba loku-1 |
| NCT02171000 | Boehringer Ingelheim | Usempilweni | Epreli 2005 | Inqanaba loku-1 |
| NCT02170844 | Boehringer Ingelheim | Usempilweni | NgoJuni 2004 | Inqanaba loku-1 |
| NCT02170584 | Boehringer Ingelheim | Usempilweni | NgoJanuwari 2001 | Inqanaba loku-1 |
| NCT02170935 | Boehringer Ingelheim | I-venous thromboembolism | Epreli 2002 | Inqanaba lesi-2 |
| NCT02170636 | Boehringer Ingelheim | Usempilweni | NgoJanuwari 2002 | Inqanaba loku-1 |
| NCT02170766 | Boehringer Ingelheim | Usempilweni | Okthobha 2000 | Inqanaba loku-1 |
| NCT02171442 | Boehringer Ingelheim | Usempilweni | Epreli 2002 | Inqanaba loku-1 |
| NCT02170896 | Boehringer Ingelheim | Usempilweni | Okthobha 2001 | Inqanaba loku-1 |
| NCT02173730 | Boehringer Ingelheim | Usempilweni | Novemba 2002 | Inqanaba loku-1 |
| NCT02170623 | Boehringer Ingelheim | Usempilweni | NgoFebruwari 2002 | Inqanaba loku-1 |
| NCT02170116 | Boehringer Ingelheim | Usempilweni | NgoNovemba 1998 | Inqanaba loku-1 |
| NCT02170597 | Boehringer Ingelheim | Usempilweni | Agasti 2003 | Inqanaba loku-1 |
| NCT01225822 | Boehringer Ingelheim | I-venous thromboembolism | Novemba 2002 | Inqanaba lesi-2 |
| NCT02170701 | Boehringer Ingelheim | I-venous thromboembolism | Okthobha 2000 | Inqanaba lesi-2 |
| NCT02170740 | Boehringer Ingelheim | Usempilweni | Novemba 1999 | Inqanaba loku-1 |
| NCT02170922 | Boehringer Ingelheim | Usempilweni | NgoJulayi 1999 | Inqanaba loku-1 |
Ubume beMichiza
Isindululo18Iiprojekthi zoVavanyo loBulunga ezivunyiweyo4, kwaye6iiprojekthi ziphantsi kolwamkelo.
Inkqubo yolawulo lomgangatho wehlabathi ephucukileyo ibeke isiseko esiluqilima sokuthengisa.
Ukongamela umgangatho kuqhuba umjikelo wobomi bemveliso ukuqinisekisa umgangatho kunye nesiphumo sonyango.
Iqela leMicimbi yoLawulo lobuGcisa lixhasa iimfuno zomgangatho ngexesha lesicelo kunye nokubhaliswa.
Korea Countec Bottled Packaging Line
Taiwan CVC Bottled UkuPakisha Line
Italy CAM Board Packaging Line
Umatshini wokuQinisa iFette waseJamani
Japan Viswill Tablet Detector
I-DCS Control Room
