Baloxavir Marboxil 1985606-14-1
Imvelaphi
I-Baloxavir marboxil lichiza le-antiviral kwaye liyi-endonuclease inhibitor. Kwiimpuku kunye neenkawu, ukuxinwa kwegazi kweyeza kuphantsi kunomlinganiselo omncinci wokufumanisa kulawulo olulodwa lomlomo lwechiza. Kwimifuziselo yosulelo lwe-preclinical influenza A kunye no-B (kubandakanywa neentlobo ezixhathisayo kumachiza asele ekhona e-antiviral), i-Baloxavir marboxil inesiphumo esithile.
Iipropati zeMichiza
| Ugcino | Gcina kwi -20°C |
| M.Wt | 571.55 |
| Inombolo yeCas. | 1985606-14-1 |
| Ifomula | I-C27H23F2N3O7S |
| Izithethantonye | S-033188 |
| Ukunyibilika | Inyibilika kwi-DMSO |
| Igama leMchiza | ((R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-6,8-dioxo-3,4,6,8 ,12,12a-hexahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl)oxy)methyl imethyl carbonate |
| SDF | Khuphela iSDF |
| Uncumo lweCanonical | O=C1C=CN(N([C@]2(N(C3=O)CCOC2)[H])[C@H]4C5=CC=C(C(F)=C5CSC6=CC=CC=C46) F)C3=C1OCOC(OC)=O |
| Imeko yokuthumela ngenqanawe | Isisombululo sesampulu yovavanyo: inqanawa enomkhenkce oluhlaza. Zonke ezinye iisayizi ezikhoyo: inqanawa nge-RT, okanye umkhenkce oluhlaza xa uceliwe. |
| Iingcebiso ngokubanzi | Ukufumana i-solubility ephezulu, nceda ufudumeze ityhubhu kwi-37 ° C kwaye uyigubungele kwindawo yokuhlamba i-ultrasonic ixesha elithile. Isisombululo sesitokhwe sinokugcinwa ngaphantsi kwe -20 ° C kwiinyanga ezininzi. |
Ubume beMichiza
Isindululo18Iiprojekthi zoVavanyo loBulunga ezivunyiweyo4, kwaye6iiprojekthi ziphantsi kolwamkelo.
Inkqubo yolawulo lomgangatho wehlabathi ephucukileyo ibeke isiseko esiluqilima sokuthengisa.
Ukongamela umgangatho kuqhuba umjikelo wobomi bemveliso ukuqinisekisa umgangatho kunye nesiphumo sonyango.
Iqela leMicimbi yoLawulo lobuGcisa lixhasa iimfuno zomgangatho ngexesha lesicelo kunye nokubhaliswa.
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