IAgomelatine
Imvelaphi
I-Agomelatine i-agonist ye-melatonin receptors kunye ne-antagonist ye-serotonin 5-HT2C i-receptor ene-Ki ixabiso le-0.062nM kunye ne-0.268nM kunye ne-IC50 yexabiso le-0.27μM, ngokulandelanayo kwi-MT1, MT2 kunye ne-5-HT2C [1].
I-Agomelatine yenye ye-antidepressant ekhethekileyo kwaye iphuhliselwe unyango lwe-depressive disorder (MDD).I-Agomelatine ikhetha ngokuchasene ne-5-HT2C.Ibonisa ubudlelwane obuphantsi kwi-cloned yabantu i-5-HT2A kunye ne-5-HT1A.Kwi-melatonin receptors, i-agomelatine ibonisa ukuhambelana okufanayo kwi-cloned human MT1 kunye ne-MT2 enexabiso le-Ki ye-0.09nM kunye ne-0.263nM, ngokulandelanayo.Kwizifundo ze-vivo, i-agomelatine ibangela ukwanda kwe-dopamine kunye namanqanaba e-noradrenaline ngokuthintela igalelo elithintelayo le-5-HT2C.Ngaphaya koko, ulawulo lwe-agomelatine luchasana nokuncipha okubangelwa uxinzelelo kusetyenziso lwe-sucrose kwimodeli yegundane yokudakumba.Ngaphandle koko, i-agomelatine inciphisa ukusebenza koxinzelelo kwimodeli ye-rodent yexhala [1].
IiReferensi:
[1] Zupancic M, Guilleminault C. Agomelatine.Iziyobisi ze-CNS, i-2006, i-20 (12): 981-992.
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